Molecular glues can stabilize protein-protein interactions (PPIs) and have emerged as a promising class of therapeutics for many “undruggable” proteins. Deep-learning approaches show enormous potential for revolutionizing structure-based drug design. However, all deep learning methods require a large training dataset containing information on the binding pocket. Such information is often unavailable for molecular glues. This … Continue reading A novel deep learning platform in design molecular glues that stabilize protein-protein interactions